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28/1/2008 Article recently published: Electrochemotherapy in treatment of tumours
A new article on electrochemotherapy named "Electrochemotherapy in treatment of tumours" by G. Sersa, D. Miklavcic, M. Cemazar, Z. Rudolf, G. Pucihar and M. Snoj was recently published in EJSO the Jurnal of Cancer Surgery, Volume 34, pages 232-240.
Aim: Electrochemotherapy is a local drug delivery approach aimed at treatment with palliative intent of cutaneous and subcutaneous tumour nodules of different histologies. Electrochemotherapy, via cell membrane permeabilising electric pulses, potentiates the cytotoxicity of nonpermeant or poorly permeant anticancer drugs with high intrinsic cytotoxicity, such as bleomycin or cisplatin, at the site of electric pulse application.
Methods: An overview of preclinical and clinical studies is presented, and the treatment procedure is further critically evaluated.: An overview of preclinical and clinical studies is presented, and the treatment procedure is further critically evaluated.
Results: In clinical studies electrochemotherapy has proved to be a highly efficient and safe approach for treating cutaneous and subcutaneous tumour nodules. The treatment response for various tumours (predominantly melanoma) was w75% complete and 10% partial response of the treated nodules.
Conclusions: Electrochemotherapy is a new, clinically acknowledged method for the treatment of cutaneous and subcutaneous tumours. Its advantages are high effectiveness on tumours with different histologies, simple application, minimal side effects and the possibility of effective repetitive treatment.
Corresponding address: gsersa@onko-i.si (Gregor Sersa)
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