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Area 02

CLINIPORATOR

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Cliniporator: a new adaptive generator for DNA electrotransfer in vivo for gene therapy

OBJECTIVES

The Cliniporator project is a combined R&D and demonstration project aimed to develop a new therapeutic strategy for effective DNA transfer in gene therapy, providing the necessary technology. The consortium will improve in vivo DNA uptake by target cells using a physical approach, the electroporation of cells in tissues. An adaptive generator will be developed which will deliver the electrical energy necessary to achieve optimal permeabilisation of the target cells in tissues and efficient DNA transfer to these cells. Hence safety for patients, reliability and effectiveness of DNA transfer for gene therapy purposes will be improved. This objective will be achieved by an initial R&D phase allowing:

  • Finding technological solutions for on-line follow-up of cell permeabilisation in tissues.

  • Modelling in vivo cell electropermeabilisation.

  • Implementing pulse control and pulse shape.

  • Elaborating an adaptive Cliniporator.

The demonstration phase will show Cliniporator effectiveness for gene transfer in different tissues.

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